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Manufacturers: Biosynthesis
Active ingredients
- Levorin
Disease class
- Changes in skin structure
- Carriage of the causative agent of another infectious disease
- Candidal stomatitis
- Candidiasis of the skin and nails
- Candidiasis of the vulva and vagina (N77.1*)
- Candidiasis of other localizations
- Cystitis
- Urethritis and urethral syndrome
- Vaginitis, vulvitis and vulvovaginitis in infectious and parasitic diseases classified elsewhere
Clinical and pharmacological group
- Antifungal antibiotics
Pharmacological action
- Antifungal
- Fungicidal
Pharmacological group
- Antifungal agents
Pharmacological properties
Pharmacodynamics
Natamycin is an antifungal polyene antibiotic from the macrolide group with a wide spectrum of action. Has a fungicidal effect. Binds to sterols of cell membranes, disrupting their integrity and functions, which leads to the death of microorganisms.
Active against most pathogenic yeast-like fungi (especially Candida albicans
), yeast
(Torulopsis and Rhodotorula)
, as well as other pathogenic fungi
(Aspergillus, Penicillium.)
.
Less active against dermatophytes ( Trichophyton, Microsporum, Epidermophyton).
Does not affect gram-positive and gram-negative bacteria in vitro.
Resistance to natamycin does not occur in clinical practice.
Pharmacokinetics
Ecofucin® does not have a systemic effect, since it is practically not absorbed through intact skin and intact mucous membranes.
Trade name: ZALAIN®
International nonproprietary name: Sertaconazole
Dosage form: vaginal suppositories
Composition for 1 suppository
Active ingredient: sertaconazole nitrate 300 mg; excipients: vitepsol 1.305 g, suppotsir 1.305 g, colloidal anhydrous silicon dioxide 0.09 g.
Description: oval-shaped, waxy, white suppositories.
Pharmacotherapeutic group: antifungal agent
ATX code: G01AF
PHARMACOLOGICAL PROPERTIES
Sertaconazole is an antifungal agent derived from imidazole and benzothiophene. It has fungistatic and fungicidal effects in therapeutic doses. Active against fungi of the genus Candida. The mechanism of action of sertaconazole is to inhibit the synthesis of ergosterol and increase the permeability of the fungal cell membrane, which leads to lysis of the fungal cell.
It also has antibacterial activity against gram-positive bacteria (staphylo- and streptococci).
PHARMACOKINETICS
There is no absorption after intravaginal use.
INDICATIONS FOR USE
Local treatment of infections of the vaginal mucosa caused by fungi of the genus Candida (vulvovaginal candidiasis).
If necessary, please consult your doctor before taking the medicine.
CONTRAINDICATIONS
Hypersensitivity to imidazole derivatives, benzothiophene and other components of the drug.
Pregnancy and lactation
There are no sufficient data on the use of sertaconazole during pregnancy and lactation. However, taking into account the method of administration of the drug (single administration), as well as the lack of systemic absorption of the drug after intravaginal administration, the use of sertaconazole during pregnancy and lactation is possible if the potential benefit to the mother outweighs the possible risk to the fetus or child .
If necessary, please consult your doctor before taking the medicine.
METHOD OF APPLICATION AND DOSES
Intravaginally, once.
Before using the drug, you must wash the external genitalia using neutral or alkaline soap.
One vaginal suppository is inserted deep into the vagina, lying on your back, before bed.
If clinical symptoms persist, the suppository may be reintroduced after 7 days.
Use the drug only according to the method of use and in the doses indicated in the instructions.
If necessary, please consult your doctor before taking the medicine.
SIDE EFFECT
Rarely: burning sensation, itching in the vagina, which disappear on their own during treatment and do not require discontinuation of the drug. These side effects are classic for topical medications and reflect the effectiveness of the drug. Allergic reactions are possible.
Consult your doctor if you experience any of the side effects mentioned or other side effects not listed above.
OVERDOSE
Not installed.
If you accidentally take the drug orally, you must rinse your stomach and consult a doctor immediately.
INTERACTION
Simultaneous use of the drug with local contraceptives may lead to a weakening of the spermicidal effect of the latter.
SPECIAL INSTRUCTIONS
In case of simultaneous infection of the labia and adjacent areas (candidal vulvitis), additional local treatment with ZALAIN cream should be carried out.
When using the drug, it is recommended to abstain from sexual intercourse.
To prevent urogenital reinfection, it is recommended to consider simultaneous treatment of the sexual partner.
The risk of condom or diaphragm rupture increases when used simultaneously with the drug.
Treatment can be carried out during menstruation.
Zalain does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving a car, etc.).
STORAGE CONDITIONS
At a temperature not exceeding 30 C. Keep out of the reach of children.
Best before date
5 years. Do not use after the expiration date stated on the packaging.
Release form
Vaginal suppository 300 mg.
1 vaginal suppository in a PVC/PE blister. 1 blister along with instructions for use in a cardboard box.
Conditions for dispensing from pharmacies
Over the counter.
Registration Certificate Holder
CJSC Pharmaceutical Plant EGIS, Hungary
1106 Budapest, st. Kereszturi ut 30-38 (1106 Budapest, Kereszturi ut 30-38, Hungary)
Phone: (36-1) 803-5555,
Fax: (36-1) 803-5529
Under license from Ferrer International A.O., Spain
Manufacturer
Trommsdorff GmbH and Co. KG, Germany, Trommsdorffstrasse 2-6, 52477, Alsdorf (Trommsdorffstrasse 2-6, 52477, Alsdorf, Germany) (all stages of production);
CJSC Pharmaceutical Plant EGIS, Hungary
1165, Budapest, st. Bokenyfoldi 118-120 (1165 Budapest, Bokenyfoldi ut 118-120, Hungary) (quality control issuer)
Name and address of the organization authorized by the holder or owner of the registration certificate of the medicinal product to accept claims from the consumer
LLC "EGIS-RUS", Russia
121108, Moscow, st. Ivana Franko, 8, phone: (495) 363-39-66
Directions for use and doses
For candidal vaginitis, vulvitis, vulvovaginitis: one suppository intravaginally for 3–6 days.
Suppositories, having previously been freed from contour packaging, are inserted into the vagina while lying down, as deeply as possible, once a day at night.
The duration of the course of treatment is determined individually. After the symptoms of the disease disappear, it is recommended to continue treatment for several more days. During menstruation, the use of suppositories is interrupted.
For persistent vaginitis caused by Candida albicans, natamycin is additionally prescribed in the form of tablets for oral administration: 1 tablet 4 times a day for 10-20 days to sanitize the focus of candidiasis infection in the intestine.
Similar drugs:
- Natamycin Substance-powder
- Lamisil Uno Topical solution
- Livarol Vaginal suppositories
- Lamisil Oral tablets
- Mycocet Ointment for external use
- Loceryl Solution for local and external use
- Lotrimin Cream for external use
- Fluomisin Vaginal tablets
- Primafungin Vaginal suppositories
- Candibene Vaginal tablets
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use Levorin, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Levorin is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Side effects
The patient’s body can give a response, which is usually expressed in diseases and conditions such as:
- Vomiting, headache, diarrhea, dizziness, nausea, as well as pain in the abdomen, loss of appetite;
- Hives, itching, redness of the skin, swelling of the face.
Overdose
In the event of an overdose, a person experiences symptoms such as:
- Head pain, dizziness;
- Diarrhea, vomiting, constipation;
- Decreased appetite;
- Fever, chills, heat;
- Severe itching, redness of the skin;
- Irritation.
If you have signs of an overdose, you need to stop taking the drug. Next, the patient is advised to go to the hospital to receive medical care.
Contraindications
A drug belonging to the group of polyenes.
It is not recommended to take this medicine if you have such concomitant diseases and conditions as:
- Severe form of liver or kidney failure;
- Pancreatitis;
- Stomach ulcer;
- Acute diseases of the gastrointestinal tract;
- Duodenal ulcer.
Caution: Levorin can be prescribed for mild to moderate renal or liver failure. In addition, the medicine is carefully prescribed for the treatment of young patients under 2 years of age.
Pregnancy period
If it is impossible to stop the drug, then taking it is allowed, however, the girl must always be under the supervision of a doctor, i.e. stay in hospital. Only such a measure will allow monitoring the negative impact on the fetus.
During breastfeeding you should refrain from taking the medicine. If it is not possible to replace the drug Levorin with a safe analogue, then taking the drug is allowed, however, before starting treatment, the issue of stopping breastfeeding must be decided.
Reviews
Reviews about this medicine are usually positive. This is due to the high effectiveness of the product. In addition, among the positive reviews, people note the convenient method of administration. The drug also has a low cost, which does not put a strain on citizens’ pockets. On the forums you can find reviews not only from patients, but also from specialists who are aware of the peculiarities of taking the medicine.
Doctors note that in 90% of cases the drug has the expected effect. You can also find neutral reviews from specialists on the Internet. Doctors note the lack of effect due to improper use of the drug. The drug Levorin has a number of negative aspects, among which it is noted that the drug is quite difficult to get at the pharmacy, as well as the presence of a large number of contraindications.
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Price
To clarify the price, you need to contact a specific pharmacy or online store. The instructions provide an approximate cost.
In Russia and Ukraine the price will differ significantly. This is due to the exchange rate and currency.
Russia
For the drug Levorin you will have to pay up to 129 rubles.
Ukraine
The medicine Levorin costs on average 59 hryvnia.
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special instructions
In this section you can find useful information.
Driving
The medicine may affect the driver while driving.
Pregnancy
During pregnancy, you should refrain from using this drug. During pregnancy, it is highly undesirable to take Levolin. This is due to the fact that the active substance can have a detrimental effect on the fetus.
It is also not recommended to take this drug while breastfeeding.
Admission in childhood
This drug can be taken from 2 years of age.
Use for kidney problems
Taking the drug is contraindicated if kidney function is damaged.
Use for liver dysfunction
Taking the medication is contraindicated if the liver function is impaired.
Release from pharmacy
Only by prescription from a doctor.
Medicine and alcohol
Taking medication and alcohol are two incompatible things.
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