How does the pill know where it hurts? FAQ about painkillers

• Three-stage pain correction system
• Types of painkillers
• How to relieve pain: a description of the stages of a three-step scheme
• How often does cancer pain occur?
• What is the reason for failure in pain treatment?
• Technologies for managing chronic pain syndromes
• Painkillers for stomach cancer
• Painkillers for lung cancer

Often the first and only symptom of cancer is pain. It causes suffering to the patient, reduces the quality of life, leads to depressive disorders, suicidal intentions and actions.

The fight against pain is a pressing problem in oncology. In order to effectively cope with pain, the doctor must correctly assess its causes, nature, and intensity.

At Euroonko, the area of ​​pain medicine is very well developed. Our doctors use all available methods, including innovative ones.

Three-stage pain correction system

The main method of treating pain in oncology is drug therapy. In the practice of Euroonko, a three-stage pain relief system of non-narcotic and narcotic analgesics is used, which allows you to effectively relieve pain and keep it under control. We take into account the recommendations of the World Institute of Pain (FIPP WIP, USA), the European Federation of the International Association for the Study of Pain (EF IASP).

The method consists of sequential use of analgesics of increasing strength in combination with adjuvant therapy as the pain intensity increases. An important principle is to begin pharmacotherapy immediately when the first signs of pain appear, before a complex chain reaction develops that leads to chronic pain syndrome. The transition to a stronger painkiller is made when all the drugs of the previous step are ineffective in their maximum dosages.

Solpadeine Fast

These painkillers act quickly, are as safe and effective as possible, and are suitable for relieving various types of pain. Solpadeine Fast contains paracetamol and caffeine. The drug is prescribed for headaches, toothaches, migraines, neuralgia, rheumatic and muscle pain, painful periods, as well as in the complex treatment of ARVI and influenza. These soluble tablets are easily absorbed and provide an immediate positive effect. The drug is prohibited for children under 12 years of age, as well as persons with hypertension, hypersensitivity to the components of Solpadeina Fast, and people with renal and liver failure. This painkiller has minimal contraindications, a quick effect, but is overpriced.

Solpadeine Fast

GlaxoSmithKline, France

- headache;
- migraine; - toothache; - neuralgia; - muscle and rheumatic pain; - painful menstruation; - a sore throat; - to reduce elevated body temperature and symptomatic treatment of colds and flu. from 77

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Types of painkillers

Pain relief begins with the prescription of non-steroidal anti-inflammatory drugs (NSAIDs) in tablet form. These include Nurofen, Eferalgan, Nimesil, Diclofenac, etc. If they are ineffective, then at the second stage, combination drugs are prescribed to eliminate moderate pain. They include weak opiates and non-narcotic analgesics. Tramadol is most often prescribed from this group due to its effectiveness and ease of use. The third stage of pain therapy involves the prescription of narcotic analgesics, which help cope with even severe pain. These include buprenorphine, morphine, fentanyl, and omnopon.

Also, corticosteroids - preparations of adrenal hormones - are often used as analgesics. They have a powerful anti-inflammatory effect, especially important for pain caused by nerve compression, headaches caused by intracranial hypertension, and bone pain.

For each patient, medications are selected individually, so there is no universal scheme.

At any stage of pain therapy, analgesics must be taken regularly by the hour. The dose is adjusted taking into account the type and intensity of pain. If the drug becomes ineffective, it is advisable to replace it with an alternative drug of similar strength, but recommend it to the patient as more powerful.

Corticosteroids - preparations of adrenal hormones - are often used as analgesics. They have a powerful anti-inflammatory effect, especially important for pain caused by nerve compression, headaches caused by intracranial hypertension, and bone pain.

Anesthesiologist-resuscitator Vadim Sergeevich Soloviev about opioid analgesics:

Our doctors follow the principles of pain therapy proclaimed by WHO:

• “By mouth” (orally)
  means that all injectable forms of analgesics should be excluded and therapy should be carried out using non-invasive dosage forms (tablets, capsules, syrups, transdermal therapeutic systems, rectal forms of drugs, etc.).
• “On the clock”
  - analgesics should be prescribed regularly according to the schedule, in accordance with the duration of the drug’s effect, without waiting for the development of severe pain, excluding the possibility of “breakthroughs” of pain.
• “Ascending”
  - the selection of drugs for pain relief is carried out from non-opioid analgesics for mild pain, “mild” opioids for moderate pain and strong opioid analgesics for severe pain, as the pain intensity increases, in accordance with the “WHO pain management ladder”
• “Individual approach”
  - implies the need for an “individual” selection of an analgesic and is based on the selective selection of the most effective analgesic in the required dose with the least side effects for each individual patient, taking into account the characteristics of his physical condition.
• “With attention to detail”
  - involves taking into account the characteristics and details of each patient, of course, prescribing co-analgesics and adjuvant agents as the need arises, and monitoring patients.

Rating of painkillers

When compiling the top rating, we held a series of consultations with leading Russian doctors on the topic of which tablets anesthetize pain of varying intensity and etiology. Taking into account their practical experience, leaders in efficiency were identified, and criteria for selecting nominees were outlined:

• Content;
• Principle of operation;
• Speed ​​of onset of effect;
• Duration of analgesic effect;
• Conditions of use;
• Age restrictions, contraindications;
• Price, manufacturer company.

The result of the comparative analysis was a top list of 13 positions. For convenience, we have divided it into 2 subsections - drugs sold in pharmacies without a prescription, as well as prescription strong painkillers for severe symptoms. Review monitoring showed the pros and cons of the nominees.

How to relieve pain: a description of the stages of a three-step scheme

Low pain therapy

The patient is prescribed non-opioid analgesics: NSAIDs (Ibuprofen, Diclofenac, Ketoprofen, etc.), Paracetamol. When choosing a drug, the toxicity to the liver and kidneys inherent in all non-opioid analgesics, as well as the gastric toxicity of non-selective NSAIDs, and the risks from the cardiovascular system when using selective NSAIDs are taken into account. It is advisable to accompany the use of first-line drugs with adjuvant and symptomatic therapy: ion pump blockers, corticosteroids, antispasmodics, benzodiazepines, antihistamines, etc.

Therapy for “moderate” pain

The oral route of drug administration is preferred if the patient can take the drugs by mouth. For patients with mild to moderate pain in whom adequate pain control is not achieved by regular oral paracetamol or non-steroidal anti-inflammatory drugs, the addition of an opioid analgesic may provide effective pain relief without adverse side effects. As an alternative, low-dose opioid analgesics (eg, morphine, TTC fentanyl) may be used.

Therapy for “severe” pain

If the pain is intense and an opioid analgesic in combination with NSAIDs or Paracetamol is ineffective, therapy with strong opioid analgesics should be started. If they were prescribed for moderate pain, you need to increase the dose of the drug until it is effective. Registered prolonged forms of strong opioid analgesics in our country and used in our clinic are: morphine in capsules and tablets, TTC fentanyl.

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Nurofen Forte

This pain reliever is the best in its category. Nurofen Forte tablets help with muscle, headache, toothache and joint pain. The drug has very few contraindications due to the content of a small amount of active ingredients. Nurofen Forte is easy to use and has virtually no side effects. Tablets are prescribed from the age of 12; you can take the drug three times a day, one tablet (at equal intervals of 6 hours). You can be treated with Nurofen Forte for no longer than two to three days, then you need to take a week break. Tablets have a wide spectrum of action.

Nurofen Forte

Reckitt Benckiser Healthcare International Ltd, UK

NSAIDs to eliminate: Headache;
migraine; toothache; algodismenorrhea; neuralgia; backache; myalgia; rheumatic pains; fever with influenza and ARVI. from 9

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How often does cancer pain occur?

Pain occurs in 30% of cancer patients who receive treatment and in 60–90% of patients due to disease progression. The main sources of cancer pain:

• cancer itself (45–90%);
• concomitant inflammatory reactions leading to spasm of smooth muscles (11–25%);
• pain in the area of ​​the postoperative wound after surgery (5–16%);
• concomitant pathology, for example, joint damage, arthritis (6–11%), neuralgia (5–15%).

Cancer pain syndromes are grouped:

• According to the origin of the pain flow: visceral, somatic, neuropathic, psychogenic.
• According to qualitative subjective assessment: burning, stabbing, cutting, drilling, pulsating.
• By intensity: assessed using special scales.
• Duration: acute and chronic.
• By localization: abdominal, cardialgia, lumbodynia, muscle-articular and others.

Due to significant differences in the mechanisms of pain, there is no universal analgesic to relieve all types of pain syndromes. Treatment should always be individualized.

Get rid of pain

The best combined action painkillers

An increase in body temperature is typical for influenza, acute respiratory infections, injuries, allergies, internal hemorrhages and cancerous tumors. Undoubtedly, in any of these cases it is important to consult a doctor in time, but the following combination drugs will help to temporarily alleviate the condition.

Reckitt Benckiser Healthcare International LTD "Nurofen Long"

5

★★★★★

editorial assessment

100%

buyers recommend this product

Tablets based on ibuprofen and paracetamol are approved for use from 2 years of age. The main indications for their use include pain and joint syndromes, bruises and inflammation of soft tissues, fever, neuralgia, dental and menstrual pain. The drug is taken 1 tablet up to three times a day and no more than 3 days. A pronounced analgesic and antipyretic effect as a result of its administration is achieved within 60 minutes and lasts up to 8 hours.

Nurofen Long is contraindicated for ulcers, gastrointestinal bleeding, in the third trimester of pregnancy and lactation. Using this medication with other NSAIDs provokes symptoms of overdose and increases their toxic effect on the body.

Advantages:

• Versatility;
• Complex action;
• Effect up to 8 hours;
• Can be prescribed to children;
• Allowed for use in the first and second trimesters of pregnancy.

Flaws:

• Combination with NSAIDs is undesirable.

Nurofen Long, thanks to its intense and long-lasting effect, will relieve severe pain in the postoperative period, and will also help with fractures, dislocations and severe bruises.

Safiston Atoll

4.9

★★★★★

editorial assessment

97%

buyers recommend this product

A highly effective remedy for headaches, dental and muscle pain in the form of tablets, intended for adults and children over 12 years of age. A combination of paracetamol, caffeine and propyphenazone is taken up to 3 tablets per day 1-2 hours after meals. The duration of such treatment should not exceed days.

The analgesic and antipyretic effect of taking the drug is achieved within an hour and lasts up to 6 hours. If doses are exceeded, dizziness, insomnia, skin rashes, vomiting and nausea are possible. The main contraindications to taking Safiston are diseases of the cardiovascular system, gastrointestinal tract, kidneys, liver, as well as periods of pregnancy and breastfeeding.

Advantages:

• Pronounced analgesic effect;
• Allowed for children;
• Long-term analgesic effect;
• Long-term use is possible without consultation with the doctor;
• Affordable price (about 150 rubles).

Flaws:

• There are many contraindications.

Safiston is a universal drug for acute pain attacks, which can be taken without fear even by teenagers - but taking into account all contraindications.

Marbiopharm "Citramarin"

4.9

★★★★★

editorial assessment

90%

buyers recommend this product

First aid for influenza, acute respiratory infections and other febrile conditions based on analgin, paracetamol and caffeine. The product in powder form is diluted in 100 ml of hot water. Frequency of administration – up to 3 times a day for no more than 5 days in a row. Failure to follow the instructions provokes vomiting, dizziness, weakness, blurred vision and bleeding gums.

Citramarin is contraindicated in pregnancy, lactation, hemophilia, hyperexcitability, renal failure, and in persons under 15 years of age. Due to its analgesic effect, the drug is also effective for neuralgia and algodismenorrhea.

Advantages:

• Pronounced antipyretic effect;
• Analgesic effect;
• Suitable for long-term use;
• Available in various flavors (orange, lemon);
• Affordable price - 200 rubles for 10 sachets.

Flaws:

• Contraindicated for children.

Citramarine is a budget antipyretic drug that will help reduce fever and relieve pain in severe bruises.

What is the reason for failure in pain treatment?

Due to the lack of specialized training in pain management, even among oncologists, and due to the perception of cancer as an incurable disease, even medical specialists often do not realize that cancer pain can be managed.

In 80–90% of patients, pain can be completely eliminated, and in the rest, its intensity can be significantly reduced. To do this, the doctor needs to take into account each of the sources and mechanisms of pain to select adequate pain therapy for cancer.

In clinical practice, we constantly encounter typical errors in the treatment of pain: unreasonably early prescription of narcotic analgesics, use of excessive dosages of drugs, non-compliance with the prescription regimen of analgesics.

The best painkillers for children

Most serious painkillers are prohibited for the youngest patients due to the lack of clinical data on their safety and large dosages of the active substance. We will tell you about painkillers that are suitable for eliminating all types of pain in babies.

Dr. Reddy's "Ibuklin Junior"

5

★★★★★

editorial assessment

100%

buyers recommend this product

A combined painkiller for children over 2 years of age has a fruity aroma and a pronounced therapeutic effect.

The product contains a combination of paracetamol and ibuprofen, which is effective for any pain syndromes of moderate severity and febrile conditions. The drug is prescribed 1 tablet 3 times a day for no more than 3 days. The therapeutic effect of taking it is achieved within one hour.

Long-term treatment and excess doses are fraught with insomnia, diarrhea, nausea, swelling and skin rashes. Contraindications to children's Ibuklin include asthma, kidney and liver diseases, and stomach ulcers. The drug can also be prescribed to women in the second and third trimesters of pregnancy.

Advantages:

• Combined action;
• Minor contraindications;
• The tablets have a pleasant aroma;
• Relieves any pain in an hour;
• Affordable price (about 150 rubles).

Flaws:

• Not suitable for long-term use.

Ibuklin Junior is a highly effective pain reliever for injuries, bruises, sprains and fractures that are inevitable in little fidgets.

Otispharm "Maxicold" for children

4.9

★★★★★

editorial assessment

92%

buyers recommend this product

Sweet syrup with intense analgesic, anti-inflammatory and antipyretic effects is approved for use from 3 months. The drug contains ibuprofen, which is effective for joint pain, dental pain and headaches, as well as stomach colic, myalgia, gout and more. The drug is taken in dosages of 20-40 mg/1 kg of body weight up to 3 times a day for up to 3 weeks.

If the instructions are not followed, vomiting, skin rash, insomnia, hyperexcitability and other symptoms of overdose are possible. Maxicold is also contraindicated in cases of kidney and liver dysfunction. This syrup is available for sale in strawberry and orange flavors, each of which will appeal to the pickiest little ones.

Advantages:

• Helps with many types of pain;
• Available in various flavors;
• Can be taken from 3 months;
• Combined action;
• Affordable price (about 200 rubles).

Flaws:

• A clear calculation of proportions is required.

Maxicold syrup is recommended as an antipyretic for children at temperatures above 38 degrees.

Technologies for managing chronic pain syndromes

Euroonko is equipped with all the necessary equipment, including individual wearable pumps and devices for dosed administration. The clinic has the licenses and permits required by the legislation of the Russian Federation. We have a well-equipped pain therapy department staffed by physicians who specialize in pain medicine.

Use the quick links to find out about the pain relief method you are interested in:

• Pain relieving patches
• Spinal anesthesia
• Epidural anesthesia
• Catheterization techniques
• Neurolysis through the gastrointestinal tract using endosonography
• Injection of drugs into myofascial trigger points
• Fascial blocks and nerve and plexus blocks
• Radiofrequency ablation
• Neurosurgical interventions
• Patient controlled analgesia (PCA)

Pain relief for stage 4 cancer can significantly improve the patient’s quality of life, reduce, and in most cases prevent suffering. This helps to give the terminally ill patient additional time during which he can actively communicate with family and friends and spend the last days of his life without painful symptoms.

Pain relieving patches

This is a method of transdermal administration of the drug. The patch contains four layers: a protective polyester film, a reservoir with the active substance (for example, fentanyl), a membrane that adjusts the release intensity and an adhesive layer. The patch can be applied anywhere. Fentanyl is released gradually over 3 days. The effect begins within 12 hours; after removal, the concentration of the drug in the blood slowly decreases. The dosage may be different, it is selected individually. The patch is prescribed, as a rule, at the very beginning of the third stage of pain relief for oncology.

Spinal anesthesia

During spinal anesthesia, the medicine is injected into the spinal canal, subarachnoidally. This leads to a temporary “switching off” of tactile and pain sensitivity. The introduction requires a certain amount of experience from the doctor. Local anesthetics and opioid analgesics are used as pain relievers. The effect is long lasting and pronounced. Mainly used for surgical interventions, for acute, unbearable pain, it has a number of side effects on the cardiovascular and respiratory systems.

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Epidural anesthesia

A more gentle method compared to the previous one. The medicine is injected into the space where the spinal nerves form. The drugs are similar to spinal anesthesia. Epidural anesthesia is used for long-term pain relief when oral and parenteral methods of administration no longer provide results.

Catheterization techniques

Catheterization techniques allow for long-term, high-quality pain relief. The introduction of port systems into the epidural and subarachnoid space with the use of local, narcotic and adjuvant drugs allows for long-term relief from pain and reduces the use of other analgesics that have their own side effects.

Neurolysis through the gastrointestinal tract using endosonography

Neurolysis (neurolysis) is the process of destruction of the nociceptive (pain) nerve pathway.

One of the most effective methods is neurolysis of the celiac (solar) plexus

, which is located in the retroperitoneal space in the upper abdomen and innervates the abdominal organs: stomach, liver, biliary tract, pancreas, spleen, kidneys, adrenal glands, large and small intestines to the splenic flexure.

The analgesic is administered transgastrically - through the gastrointestinal tract; accuracy is ensured by endoscopic ultrasound control. Such methods of local anesthesia are used, for example, for pancreatic cancer with an effectiveness of up to 90%

. The analgesic effect can last for more than several months, while narcotic analgesics would have to be administered continuously using the classical method.

Injection of drugs into myofascial trigger points

Myofascial pain syndrome is expressed in muscle spasm and the appearance of painful lumps in tense muscles. These are called trigger points and are painful when pressed. Injections into the trigger zone relieve pain and improve mobility of the body area. The purpose of trigger point injections is to “break” the pain cycle of pain-spasm-pain. They successfully treat spasms of many muscle groups, especially in the arms, legs, lumbar region and neck, and head. Often used as adjunctive therapy for fibromyalgia and tension headaches.

Fascial blocks and nerve and plexus blocks

The same qualitative effect is provided by fascial blockades and blockades of nerves and plexuses.

A nerve or plexus block involves injecting a drug near the nerve that connects to the affected organ and causes pain. Peripheral blockade procedures are performed by experienced specialists using ultrasound navigation, which allows for more precise administration of the analgesic drug to the required location without affecting or damaging the nerve structures.

The use of hormonal drugs during blockade can eliminate pain for a long time, and repeated blockade can eliminate pain for several months

. Depending on the type of anesthetic, the procedure is carried out once a year, once every six months or every week. Another plus is the minimal number of negative consequences.

Radiofrequency ablation

This technology is based on selective thermocoagulation of certain nerves with special electrodes. The affected area is carefully controlled, allowing very small areas to be treated without damaging nearby motor and sensory nerves. Recovery after the procedure occurs very quickly and with almost no consequences, which allows the patient to return to normal life.

The procedure can be performed without hospitalization. Radiofrequency destruction gives a long-lasting effect that can last up to a year or more

.

The incidence of complications and side effects is very low. If the pain returns, treatment may be repeated.

Write to an oncologist

Patients with obvious mental disorders, with secondary pain or drug addiction are an unsuitable population for neurodestructive manipulations. Such patients may continue to complain of pain even if the procedure is successful. The patient must have a realistic view of the outcome of treatment. He must understand that the goal is to reduce pain, not completely eliminate it.

a diagnostic blockade is required.

. A good effect of a diagnostic blockade can predict a satisfactory result of neurodestruction. However, the same diagnostic block must be repeated at least one more time, even if the pain relief was significant, to negate the placebo effect.

If the result is not entirely clear, differential blocking should be used. In patients with widespread or multilocal pain, the outcome of treatment usually does not meet expectations. The patient should be aware that targeting one area may not achieve the desired effect and may require additional destruction to achieve maximum pain relief.

Euroonco doctors talk about radiofrequency ablation:

The procedure should be avoided on mixed nerves as it may result in loss of skin sensation and muscle weakness. Deafferentation pain can be aggravated by destruction of the damaged nerve. When pain is of central origin (spinal or higher), peripheral nerve destruction may cause an increase in pain perception due to the elimination of incoming stimulus. The best alternative in this case is neuroaugmentation with TENS or spinal cord stimulation.

Neurosurgical interventions

During the procedure, the neurosurgeon cuts the spinal or cranial nerve roots through which the nerve fibers pass. Thus, the brain is deprived of the ability to receive pain signals. Cutting the roots does not lead to loss of motor ability, but may complicate it.

Patient controlled analgesia (PCA)

This type of pain relief is based on a simple rule: the patient receives analgesics when he wants it. The scheme is based on individual perception of pain and the need to take analgesics. In European countries, RSA has been accepted as the standard for postoperative pain management. The method is simple and relatively safe

. However, patients must be thoroughly instructed.

PCA is most effective when using catheter methods (epidural, spinal anesthesia, nerve plexus block with catheter installation), as well as port systems, both venous and epidural and intrathecal.

Which painkillers are better

It is impossible to clearly choose which tablets are better. Not only the composition and principle of operation decide a lot, but even the quality of raw materials and production technology. The Vyborexperta.ru rating presents 13 current proposals, and several nominees stand out in particular:

• Nurofen forte – triple action and pronounced pain relief due to the increased concentration of NSAIDs;
• Nexemesin - prolonged pain relief, relief of inflammation, reduction of fever, help with menstruation and joint problems;
• Paracetamol is a popular choice, acceptable for use in childhood, pregnancy and breastfeeding;
• Pentalgin is a polycomposition that works to relieve spasms, relieve inflammation, and suppress pain symptoms;
• Ibuklin - emergency care for high temperatures, a wide range of pain relief, the presence of a children's form;
• Diclofenac retard Obolenskoe - good help for pathologies of the musculoskeletal system, joints, muscles, prolonged work;
• Ketonal DUO is a fast and at the same time prolonged action, a multifunctional medicine in the form of capsules, gentle on the stomach.

The pharmaceutical market offers a wide range of modern analgesics. You should not use them frequently or on an ongoing basis without your doctor's approval. They can mask the clinical picture, making timely detection of diseases difficult.

Painkillers for stomach cancer

About 70% of patients suffering from stomach cancer experience discomfort and pain. As a rule, pain is localized in the abdomen, but as the tumor progresses it can also occur in other places: in the back, ribs, bones. Neuropathic pain may occur as a symptom of paraneoplastic syndrome or a side effect of chemotherapy.

In addition to the three-step system, benzodiazepines, antidepressants, adrenal hormones (prednisolone, dexamethasone), sleeping pills, and antipsychotics are used to combat pain and discomfort in stomach cancer. For bone pain and pathological fractures, bisphosphonates are prescribed.

The doctor can perform two types of nerve blocks:

1. Celiac plexus block
   helps relieve pain in the upper abdomen. The conduction of pain impulses through the nerves of the stomach, liver, pancreas, gall bladder, intestines, and kidneys is blocked.
2. Hypogastric plexus block
   helps relieve pain in the lower abdomen. During it, the nerves of the lower intestine, bladder, testicles, penis, prostate, uterus, ovaries, and vagina are blocked.

Plexus blocks can be performed using anesthetics and drugs that temporarily damage the nerves. With neurolysis, a drug is administered that destroys the plexus.

Drotaverine

Perhaps one of the most inexpensive and effective antispasmodics prescribed for pain in the gastrointestinal tract and spasms of the smooth muscles of internal organs. "Drotaverine" has very few contraindications: childhood, intolerance to the drug components, severe liver and kidney failure. Drotaverine contains a low concentration of the active substance, so the risk of side effects is practically eliminated. Due to its low cost, this painkiller is available to everyone. Among the disadvantages is that sometimes Drotaverine is difficult to find in pharmacies.

Drotaverine

Planet Organics; Borisov medical plant drugs, Belarus; NPC Pharmzashchita, Russia; PJSC "Biosintez", Russia; Ozon LLC, Russia; FSUE "Armavir Biofactory", Russia; PJSC "Biokhimik", Russia; Deco, Russia; JSC Dalkhimfarm, Russia; Novosibkhimpharm OJSC, Russia; Vifitech/Vilar, Russia; Update, Russia; Sintez OJSC, Russia; JSC PharmProject, Russia; PJSC Valenta Pharm, Russia; "Moskhimfarmpreparaty" named after. N. A. Semashko, Russia; JLLC "Lekpharm", Belarus; Medisorb, Russia; Obolensk pharmaceutical enterprise, Russia; Solopharm, Grotex LLC, Russia; Ellara MC, Russia

Spasm of smooth muscles of the urinary and biliary organs (renal colic, pyelitis, tenesmus, biliary colic, intestinal colic, dyskinesia of the biliary tract and gallbladder of the hyperkinetic type, cholecystitis, postcholecystectomy syndrome).
Spasm of smooth muscles of the gastrointestinal tract (usually as part of combination therapy): pylorospasm, gastroduodenitis, gastric and duodenal ulcers, spastic constipation, spastic colitis, proctitis. Tensor headache. Dysmenorrhea, threatened miscarriage, threatened premature birth, postpartum contractions. When conducting some instrumental studies, cholecystography. from 12

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Painkillers for lung cancer

The cause of chest pain due to lung cancer can be the tumor itself or a surgical procedure. Other possible reasons:

• Metastases in the brain lead to headaches.
• Metastases of the abdominal organs lead to abdominal pain.
• Metastases in the bones lead to bone pain and pathological fractures.
• Paraneoplastic syndrome leads to neuropathic pain in different parts of the body.
• Pain is one of the side effects of chemotherapy.

In addition to pain-relieving injections for lung cancer with NSAIDs and narcotic analgesics, other drugs, nerve blocks, radiation therapy, and palliative surgical interventions help.

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Aspirin Express

These effervescent pain relief tablets contain 500 mg of acetylsalicylic acid. After taking this pill, the headache will go away within 15 minutes. "Aspirin Express" relieves pain, relieves inflammation and works as an antipyretic. The drug is prescribed to patients over 25 years of age, and it is important that the person does not have diseases of the gastrointestinal tract, kidneys or liver. Aspirin Express is prohibited for pregnant and lactating women. For migraines, you need to dissolve two effervescent tablets in a glass of water. 1 tablet – 1 g (you can take no more than 3 g of the drug per day). If you exceed the permissible dosage of these pain pills, side effects such as dizziness, nausea, vomiting, and the development of an allergic reaction are possible. You should not take Aspirin Express for more than three days (without consulting your doctor). The drug has a complex effect, a quick effect, a convenient release form, and no side effects. You can read the contraindications in the instructions.

Aspirin Express

Bayer AG, Germany

Antipyretic, analgesic, anti-inflammatory, antiplatelet agent, NSAID for the symptomatic relief of headache, toothache, sore throat, menstrual pain, muscle and joint pain, back pain;
- increased body temperature during colds and other infectious and inflammatory diseases (in adults and children over 15 years of age). from 156

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