The drug "Stomatofit® A" in the complex treatment of inflammatory periodontal diseases

From this article you will learn:

• reviews on Stomatofit,
• Features of use for gum inflammation, stomatitis,
• price of the drug in pharmacies for 2022.

Stomatofit is a line of medicines that are prescribed by dentists for the treatment of inflammatory diseases of the gums and oral mucosa. Manufacturer – pharmaceutical (Poland). The drug has 5 release forms. The main forms of release are in the form of a spray, a concentrated solution and a product for lubricating erosions during stomatitis. There are also 2 types of rinses, one of which is intended for children from 6 years old, and the other for teenagers from 14 years old and adults.

The active components of the Stomatofit line of drugs are extracts and essential oils of 7 types of medicinal plants - chamomile, oak bark, sage, arnica, calamus, thyme and peppermint. In addition, the drug “Stomatofit A” additionally contains anesthesin, which anesthetizes erosions due to stomatitis. As for rinses, they additionally contain fluorides, xylitol and thymol, but the concentration of plant extracts themselves in them will be significantly lower (compared to other forms).

Line of drugs Stomatofit –

In this article we will talk about the indications for the use of Stomatofit drugs, the features of their use in the treatment of gum inflammation and stomatitis, positive as well as negative properties that do not always allow their use in some groups of patients. Below we will analyze in order the following forms of release of this drug -

• Stomatophyte (in the form of a solution),
• Stomatofit Expert (spray),
• Stomatofit A (with anesthesin),
• 2 rinses from the Stomatofit Fresh series.

Stomatofit analogues

This page provides a list of all Stomatofit analogues by composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.

• The cheapest analogue of Stomatofit: Eucalyptus tincture
• The most popular analogue of Stomatofit: Tantum Verde
• ATC classification: Other drugs for the treatment of oral diseases
• Active ingredients/composition: Calamus, Arnica montana, Common oak, Peppermint, Chamomile, Thyme, Salvia officinalis

When calculating the cost of cheap analogues of Stomatofit, the minimum price was taken into account, which was found in the price lists provided by pharmacies

This list of drug analogues is based on statistics of the most requested drugs

All analogues of Stomatofit

Analogues in composition and indications for use

The above list of drug analogues, which contains substitutes for Stomatofit , is the most suitable, since they have the same composition of active ingredients and coincide in indications for use

Analogues by indication and method of use

Different composition, may have the same indication and method of use

How to find a cheap analogue of an expensive medicine?

To find an inexpensive analogue of a medicine, a generic or a synonym, first of all we recommend paying attention to the composition, namely the same active ingredients and indications for use. The same active ingredients of a drug will indicate that the drug is a synonym for the drug, pharmaceutically equivalent or a pharmaceutical alternative. However, we should not forget about the inactive components of similar drugs, which may affect safety and effectiveness. Do not forget about the instructions of doctors; self-medication can harm your health, so always consult a doctor before using any medication.

Stomatofit price

On the websites below you can find prices for Stomatofit and find out about availability at a pharmacy near you

Stomatofit instructions

INSTRUCTIONS for use of the drug Selzinc Plus

Release form Film-coated tablets

Composition 1 film-coated tablet contains: selenium 0.05 mg, zinc 8 mg, beta-carotene 7.2 mg, vitamin E 35 mg, ascorbic acid 180 mg

Packaging There are 30 tablets in a package.

Pharmacological action Selzinc Plus is a dietary supplement; a combined antioxidant containing a complex of microelements and vitamins: selenium, zinc, vitamin E, vitamin C and beta-carotene. Zinc ions are a cofactor in the superoxide dismutase enzyme system, which catalyzes the disproportionation reaction of free radicals. In addition, zinc ions are necessary for the activity of hydrolases (phosphatase, peptidase, kinase), which are involved, in particular, in the transfer of phosphate; play an important role in the metabolism of nucleic acids, proteins, fats, carbohydrates, fatty acids, hormones (including sex hormones). Selenium ions are a cofactor in the enzyme system glutathione peroxidase, which decomposes hydrogen peroxide through the simultaneous oxidation of reduced glutathione. Vitamin E (alpha-tocopherol) has high antiradical activity, providing protection of unsaturated fatty acids in membranes from the phenomenon of lipid peroxidation and participating in the formation of intercellular substance, collagen and elastic fibers of connective tissue, vascular smooth muscles, and the digestive tract. Vitamins with antioxidant properties also include vitamin C (ascorbic acid), which, in addition, ensures the synthesis of collagen, is involved in the metabolism of folic acid and iron (see iron salts), plays an important role in the synthesis of steroid hormones and catecholamines, beta- carotene is a fat-soluble plant pigment from the group of carotenoids, entering the body, accumulates in it and turns into retinol (vitamin A), which, interacting with various opsins, participates in the formation of visual pigments necessary for normal twilight and color vision; ensures the integrity of epithelial tissues, regulates bone growth.

Selzinc Plus, indications for use Increased need for microelements and vitamins during colds, viral and bacterial infections, as well as radiation and chemical exposure to the environment Poor nutrition, leading to a deficiency of microelements and vitamins with antioxidant activity. Chronic inflammatory diseases of the gastrointestinal tract Increased physical and psycho-emotional stress Excessive alcohol consumption Diabetes mellitus Menopause

Contraindications: Individual intolerance to the components of Selzinc Plus, pregnancy and breastfeeding.

Method of administration and dosage Selzinc Plus is taken orally. Adults: 1 tablet 1 time per day, during meals. Duration of treatment is 1 month.

Side effects In rare cases, allergic reactions are possible when taking Selzinc Plus.

Special instructions Before use, consult a doctor.

Storage conditions: In a dry place, protected from light, at a temperature not exceeding 20°C.

Shelf life: 2 years.

Stomatophyt ® (Stomatophyt)

Content

• Composition and release form
• pharmachologic effect
• Pharmacodynamics

• Indications for the drug Stomatofit
• Contraindications
• Interaction

• Directions for use and doses
• Storage conditions for the drug Stomatofit
• Shelf life of the drug Stomatofit

• Prices in pharmacies

Pharmacological group

Nosological classification (ICD-10)

• B37.0 Candidal stomatitis
• K05.2 Acute periodontitis
• K05.4 Periodontal disease
• K06.8 Other specified changes in the gingiva and edentulous alveolar margin
• K06.9 Change in gingiva and edentulous alveolar margin, unspecified
• K12 Stomatitis and related lesions
• K14.9 Disease of tongue, unspecified

Composition and release form

in dark glass bottles of 45 or 120 ml, complete with a measuring cup; in a cardboard pack.

pharmachologic effect

Pharmacodynamics

The drug has an astringent, emollient, anti-inflammatory effect on the oral mucosa due to the content of extracts of oak bark, sage leaves and chamomile flowers. In addition, tannins and essential oils contained in the preparation have an antiseptic (antibacterial and antifungal effect) on the mucous membrane of the oral cavity and gums. In vitro tests

have proven that essential oils of sage and chamomile have a bactericidal effect against gram-positive and gram-negative bacteria, as well as a fungicidal effect against
Candida albicans
.

Indications of the drug Stomatofit ®

serous-purulent inflammation of the gums and oral cavity;

superficial and deep periodontitis;

serous inflammation of the tongue;

tendency to bleeding gums and periodontal disease;

zoonotic inflammation of the oral cavity;

fungal inflammation of the oral mucosa caused by yeast.

Contraindications

Allergy to arnica, chamomile and other plants of the genus Asteracae.

Interaction

Adverse interactions are still unknown. For this reason, the drug can be combined with other drugs.

Directions for use and doses

Rinse with a 15% aqueous solution of the drug (dissolve about 10 ml of the drug in 1/4 cup of boiled water).

Storage conditions for the drug Stomatofit ®

Keep out of the reach of children.

Shelf life of the drug Stomatofit ®

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Prices in Moscow pharmacies

175.00 To the pharmacy

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Current information demand index, ‰

Registration certificates Stomatofit ®

• P N013059/01

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Commercial use of materials is not permitted.

The information is intended for medical professionals.

Rinse aid “Stomatofit Fresh” –

Stomatofit Fresh is a mouth rinse solution that helps strengthen teeth and gums and give fresh breath.
Can be used in adults and children over 14 years of age. The drug does not contain alcohol, so it is safe for motorists, pregnant and lactating women. For Stomatofit Fresh, the price in pharmacies starts from 130 rubles per 250 ml bottle. The composition of this rinse is very different from previous products in the Stomatofit line of drugs. The composition is broader, but the concentration of medicinal plant extracts here is much lower, which, in principle, makes this drug only a means for the prevention of gum inflammation (but not for treatment), as well as for giving freshness to the oral cavity + strengthening teeth with fluoride.

Composition and release form –

Composition analysis - essential oils, castor oil, thymol have an anti-inflammatory effect. Sodium fluoride strengthens tooth enamel, and xylitol normalizes the acidity of the oral cavity, which ultimately results in an anti-caries effect. In addition, essential oils and menthol help temporarily mask the appearance of bad breath (halitosis).

Directions for use and dosage: rinse your mouth 2 times a day for 1 minute. Does not require dilution with water. Take about 10 ml of the drug into your mouth (rinse for 1 minute, without spitting). Do not swallow. After rinsing, do not rinse your mouth with water. An important point is that you need to use the mouthwash only after brushing your teeth (and during the period of using the mouthwash, it is best to use toothpastes with calcium, without fluoride).

Stomatofit Fresh: reviews

Decent composition, attractive price. Does not contain chemical antiseptics, antibiotics, alcohol, making it suitable for constant use. Sodium fluoride strengthens tooth enamel well and prevents the formation of caries. The anti-caries effect will be higher if you use toothpaste with calcium rather than fluoride before rinsing your mouth.

Essential oils will freshen your breath and also have an anti-inflammatory effect on the oral mucosa, which is important for preventing exacerbation of chronic gum inflammation. Stomatofit Fresh is more suitable as a means for strengthening teeth, creating freshness in the oral cavity, and also for preventing gum inflammation. But the drug is not suitable for the treatment of gum inflammation, because... contains too small concentrations of anti-inflammatory components, which also do not have a noticeable antiseptic effect.

→ Rating of mouthwashes for gum inflammation

Stomatophyte

Composition of Stomatofit

At their core, Stomatofit and Stomatofit A are two drugs with similar effects, which differ slightly in chemical composition.

Both drugs are intended for external use. They are a solution and contain in different proportions such active medicinal compounds as extracts of sage leaves, chamomile flowers , calamus rhizomes , oak bark , arnica herbs , thyme and peppermint .

However, Stomatofit A, among other things, contains anesthesin .

Release form

The medicinal solution is produced in dark glass bottles with a measuring cup with a nominal volume of 45 or 120 ml. One cardboard package contains one bottle.

The medicinal extract Stomatofit A is also packaged in dark glass bottles with a measuring cup with a nominal volume of 25 ml. One bottle is included in one cardboard package.

pharmachologic effect

The drugs have anti-inflammatory properties .

Pharmacodynamics and pharmacokinetics

Both one and the other preparation contain components of plant origin. Both drugs have antimicrobial, astringent, anti-inflammatory and fungicidal properties.

Thanks to the content of extracts of oak bark, sage and chamomile flowers, both medicines are effective in combating inflammatory processes, and also accelerate regeneration and soften the oral mucosa.

The content of tannin compounds in the composition of the preparations helps the immune system fight gram-negative as well as gram-positive bacteria and yeast fungi of the species Candida albicans.

Indications for use

Both drugs are used in the therapeutic treatment of diseases such as:

• inflammation of the oral cavity caused by the yeast Candida albicans;
• inflammation of the tongue;
• gingivitis;
• periodontitis;
• glossitis;
• stomatitis.

Both drugs are prescribed for a tendency to periodontal disease and bleeding gums, both as part of complex therapy and as a monotherapeutic agent.

Contraindications

Both drugs are not recommended for use in case of individual intolerance to some of the herbal components included in their chemical composition. The most common allergic reaction is to plants from the genus Asteracae, for example, chamomile or arnica.

Side effects

As a rule, patients tolerate these drugs well. However, in some cases, the medicine can cause an unpleasant burning sensation, as well as a change in the color of the tooth enamel, which disappears immediately after stopping use of the medicine.

Instructions for use of Stomatofit (Method and dosage)

The solution for external use (10 ml) is diluted with water in a proportion of ¼ immediately before use. The oral cavity is rinsed with the solution 3-4 times a day for two weeks. For the correct dosage of the drug, it is better to use a measuring cup. The mode of use of the medicine, as well as its dosage, may vary depending on the prescription of the attending physician.

Instructions for Stomatofit A

The extract is used to treat the mucous surface of the oral cavity. The affected areas are lubricated with the medicine using a cotton pad. After using the drug, do not drink, eat or rinse your mouth for half an hour. For effective treatment, it is recommended to use the medicinal extract 4 times a day.

Overdose

According to the manufacturer's information, an overdose is impossible when using the drugs. If you accidentally get the medicine into your stomach, you should immediately rinse it and seek medical help.

Interaction

When using several drugs together to treat the throat or oral cavity, a half-hour interval should be observed between taking Stomatofit and the medications listed above.

Terms of sale

Dispensed without a doctor's prescription.

Storage conditions

To preserve the medicinal properties of the drug, it should be stored in a dark place, out of reach of children, at a temperature not exceeding 25°C.

Best before date

special instructions

The chemical composition of the drugs contains up to 70% ethanol.

Stomatofit A (with anesthesin) –

Stomatophyte A is a viscous liquid of dark brown color, with a characteristic herbal-medicinal odor. The drug is intended for application with a cotton swab to the surface of erosions and ulcers on the oral mucosa that form due to stomatitis or when wearing removable dentures. The drug is available in bottles of 25 g - at a price of 170 rubles.

Composition and release form –

Analysis of the composition - the drug "Stomatofit A" contains the same list of medicinal plant extracts as the 2 previous forms of the drug Stomatofit. Additionally, the drug contains anesthesin, which has a local anesthetic effect. Additional components can also contain alcohol, as well as a special thickener, which improves the fixation of the drug on the moist mucous membrane of the oral cavity.

Contraindications for use –

• the presence of allergic reactions to any of the components of the drug,
• in children under 18 years of age,
• during pregnancy and lactation,
• use by motorists is possible, but with caution.

Method of administration and dosage - shake the bottle of the drug, then use a cotton swab to apply the solution to areas of the oral mucosa that have erosions or ulcers. After this, you should refrain from eating and rinsing your mouth for several hours. Treatment is carried out 3-4 times a day, the course of treatment is no more than 5 days.

Reviews for Stomatofit A (with anesthesin) –

With various diseases in the oral cavity, painful erosions or ulcers can form, which cause a lot of discomfort, interfering with normal oral hygiene and comfortable eating. Most often, ulcers occur either with herpetic stomatitis or with aphthous stomatitis. There are not many drugs for their pain relief, and this is where Stomatofit A can help. The analgesic effect lasts for several hours.

Photos of ulcerations with stomatitis -

It should be noted that the use of Stomatofit A for stomatitis is not a specific treatment and can only be recommended as part of complex therapy. The drug has only an analgesic and anti-inflammatory effect, but does not in any way affect the causes of stomatitis. Those. the drug only helps to reduce the severity of symptoms, but does not affect the duration of the disease.

Alternative drugs for pain relief for painful erosions and ulcers in the oral cavity can be Cholisal-gel, Kamistad-gel or Tantum Verde. It should be noted that long-term use of the drug Stomatofit A is not recommended due to the toxic effect of anesthesin on the oral mucosa, which can slow down the epithelization of ulcers. Those. It is better to use the product only in a short course specifically to reduce the pain of erosions and ulcers in the acute period of stomatitis.

Stomatophyte

The instructions for use position the medicine Stomatofit as a herbal remedy with astringent and anti-inflammatory properties. Produced by Polish and Russian pharmacists. Dentists prescribe this drug for the treatment of stomatitis, gingivitis and periodontal disease.

1. Release forms and composition
2. Stomatofit Fresh
3. Stomatophyte for children
4. Indications for use
5. Instructions for use of Stomatofit: dosages and rules of administration
6. Pharmacokinetics and pharmacodynamics
7. Side effects
8. Children, pregnancy and breastfeeding
9. Drug interactions
10. Features of application
11. Prices in pharmacies
12. Conditions of release and storage
13. Similar means

Release forms and composition

The drug Stomatofit is available in the form of a liquid extract for local use in dark glass bottles of 45 and 120 ml in a cardboard box with detailed instructions included.

The contents of the bottle are a yellowish or brown liquid with a characteristic herbal odor. The product comes with a measuring cup for ease of use and precise dosing.

The composition of the drug includes:

• arnica herb;
• chamomile flowers;
• common thyme herb;
• peppermint leaves;
• sage herb extract;
• Oak bark;
• rhizomes of calamus.

The medicinal extract Stomatofit A is also packaged in dark glass bottles with a measuring cup with a nominal volume of 25 ml. One bottle is included in one cardboard package. Stomatophyte A additionally contains anesthesin.

Stomatofit Fresh

The product is used to protect teeth from caries, counteract the darkening of enamel, and eliminate bad breath. It is sold in 250 ml containers and is not used for children under 6 years of age or for those with individual intolerance. The medicine has no side effects.

The approximate dose for effective rinsing is 10 ml. For correct dosing, a measuring cup is included with the bottle of the drug. The procedure takes 30 seconds and is carried out in the morning and evening after each brushing of the teeth. Swallowing the product is prohibited. After the procedure, in order to avoid premature rinsing of the components, you should not rinse your mouth with water.

Contains:

• xylitol;
• sodium fluoride;
• menthol and eucalyptus;
• Castor oil;
• thymol;
• essential oils - sage, eucalyptus, mint, thyme.

Stomatophyte for children

The product is used to treat inflammatory diseases of the oral cavity. Release form: 250 ml bottles. It is not used in cases of hypersensitivity to the components of the composition; it has no side effects.

To prepare the solution, you need to dilute 7.5 ml of the drug in 50 ml of boiled warm water. You can rinse your mouth with the resulting suspension for a minute after brushing your teeth, morning and evening (maximum 4 times a day). Duration of therapy is 10–15 days. Repeating the course is permissible according to the doctor's decision.

Children aged 6 years and older can use this medicine. This drug should be used to rinse the child's mouth. The composition is similar to Stomatophyte Fresh. But the ingredients exclude substances that are unsafe for the younger generation. Specifically, no alcohol. But numerous essential oils are included. They have a positive effect on the oral health of children.

If a child accidentally swallows the product, nothing bad will happen. There may be some discomfort that passes quickly.

Do not use the drug if the child is allergic to any component. To avoid accidents, you need to carefully read the instructions for use. Feedback from parents and children is very positive, which is encouraging. They say that rinsing with stomatophyte brings pleasure to the baby.

Indications for use

What does Stomatofit solution help with? The medicine is used in the therapeutic treatment of diseases such as:

• stomatitis;
• inflammation of the oral cavity caused by the yeast Candida albicans;
• periodontitis;
• gingivitis;
• glossitis;
• inflammation of the tongue.

The extract is prescribed for those with a tendency to periodontal disease and bleeding gums, both as part of complex therapy and as a monotherapeutic agent.

Instructions for use of Stomatofit: dosages and rules of administration

The standard course of rinsing with the extract is two weeks. The maximum number of cavity treatments is 3-4 times a day.

The bottle of medicine is accompanied by a special measuring cup. The medicine must be shaken before mixing. Standard dosage: 10 ml extract x 50 ml warm water.

The frequency of rinsing depends on the doctor's prescription. The solution can be used for preventive purposes in the morning after brushing your teeth in the same concentration. Dentists recommend using a deodorizing product instead of regular mouth rinses.

After rinsing, it is not recommended to eat or drink for half an hour. The medicine should have maximum effect on the affected areas and be absorbed into the tissue.

Pharmacokinetics and pharmacodynamics

According to the instructions, Stomatofit has an anti-inflammatory, softening, astringent effect on the oral mucosa, which is ensured by the content of extracts of oak bark, chamomile flowers and sage leaves.

In addition, the essential oils and tannins contained in the preparation have an antiseptic (antifungal and antibacterial) effect on the mucous membrane of the oral cavity and gums.

Side effects

According to the instructions for use stated by the manufacturer, no cases of negative effects on the body caused by exceeding the permissible concentration of the solution were found.

If the drug accidentally enters the stomach organs undiluted, rinsing and subsequent consultation with a specialist are required.

Occasionally, side effects may occur due to the effect of the drug:

• redness and itching of the mucous membrane in patients prone to increased sensitivity of soft tissues;
• slight pigmentation of the tooth enamel surface, which gradually disappears after stopping the course of treatment;
• mild burning sensation in the mouth.
• Contraindications
• for drivers (contains alcohol);
• during pregnancy and lactation;
• up to 18 years old;
• if you are allergic to substances included in the composition.

Children, pregnancy and breastfeeding

During pregnancy, these medications are recommended to be used only if there is a medical need. The drug is not recommended for use in the treatment of children under six years of age.

Drug interactions

There are no data on the interaction of Stomatofit with other drugs/substances.

Features of application

After rinsing the mouth with the drug solution, you should avoid eating or drinking water for 1 hour.

When storing the drug, a small amount of sediment may form; before diluting the drug, the bottle should be shaken vigorously.

Prices in pharmacies

• A 50 ml bottle of Stomatofit will cost the buyer 155 - 175 rubles;
• Stomatofit A in 25 g packaging costs 163 rubles;
• Stomatofit Fresh for adults and children – 126 – 142 rubles per 250 ml bottle.

Conditions of release and storage

The drug is approved for use as a means of OTC. Keep away from children. To preserve the medicinal properties of the drug, it should be stored in a dark place at a temperature not exceeding 25°C. Shelf life: 3 years.

Similar means

1. OKI;
2. Ambassador;
3. Metrogil Denta;
4. Grammidin;
5. Bacterial balance;
6. Maraslavin;
7. Grammidin neo;
8. Anti Angin Formula;
9. Dentamet;
10. Imudon;
11. Erbisol;
12. Abisil;
13. Trypsin crystalline;
14. Sodium nucleinate;
15. Tantum Verde.

Stomatofit Expert (spray) –

Stomatofit Expert has exactly the same composition as regular Stomatofit (concentrated rinse solution) - only in the form of a spray.
This makes it possible to use the drug anywhere, for example, at work, in the car or outdoors, and eliminates the need to dilute the concentrated solution of Stomatofit with water. For Stomatofit Expert, the price starts from 300 rubles for a 50 ml spray bottle, which is significantly more expensive compared to a regular concentrated rinse solution. This drug is also not recommended for use by children under 12 years of age, when driving vehicles, or by pregnant and lactating women. The course of application is 10 days, 4 times a day.

Which release form of Stomatofit is right for me?

Inflammatory diseases of the oral mucosa bring severe discomfort: pain, bleeding gums, unpleasant odor, difficulty drinking and eating, as well as temperature and swollen lymph nodes. This condition reduces performance and does not have the best effect on mood, so many people strive to take some measures to get rid of unpleasant symptoms.

The optimal solution is to visit a dentist, who will accurately determine the type of disease (stomatitis, gingivitis, periodontitis) and prescribe appropriate treatment. Self-medication in such cases is fraught with aggravation of the inflammatory process. Even the most popular and really good products will not bring any effect if the application and dosage are incorrect.

For complex therapy of inflammatory diseases of the oral cavity, doctors often prescribe herbal remedies, for example, “Stomatofit®” and “Stomatofit® A”. Which drug is suitable for the patient depends on the type of pathology identified, the degree of its development, and the presence of associated problems.

Differences between the drugs "Stomatofit®" and "Stomatofit® A"

Both drugs are herbal based and include extracts of medicinal plants. "Stomatofit®" is a liquid extract for rinsing the mouth. It is prescribed if inflammation is not accompanied by pain or the pain syndrome is insignificant. "Stomatofit®" is recommended for use from 12 years of age. It contains an extract from 7 types of plant materials:

• oak bark,
• sage leaves,
• calamus rhizomes,
• chamomile flowers,
• peppermint herbs,
• arnica herbs,
• thyme herbs.

To use the drug “Stomatofit®”, 7.5 ml of the product is diluted in ¼ cup of warm boiled water. Use the drug as recommended by the dentist, usually three to four times a day for 10-15 days.

"Stomatofit® A" is a viscous liquid with which applications are made on the gums or lubricated. It contains an extract from the same 7 plants. The drug is prescribed for severe pain syndrome accompanying inflammatory diseases of the oral cavity. Thanks to the thickener, the active components remain on the surface of the gums for a long time. The composition contains anesthesin, which relieves pain.

"Stomatofit® A" can be used from 18 years of age. The drug is used for inflammatory diseases of the oral cavity and ulcerative lesions of the oral mucosa caused by dentures, for canker sores and periodontal disease (as an adjuvant). "Stomatofit® A" has the following properties:

• anti-inflammatory,
• antimicrobial*,
• antiseptic,
• antifungal*,
• astringent,
• hemostatic*.

"Stomatofit® A" is applied to lesions of the oral mucosa three times a day, the duration of therapy is determined by the doctor.

After using any product, you must refrain from eating and drinking for 30 minutes.

Thus, the choice of the form of the drug depends on the severity of the pain syndrome, the type of disease of the oral mucosa, and the age of the patient. The right medicine helps reduce unpleasant symptoms and get rid of the cause of inflammation.

The drug "Stomatofit® A" in the complex treatment of inflammatory periodontal diseases

L. N. Maksimovskaya Doctor of Medical Sciences, Professor, Honored Doctor of the Russian Federation, Head of the Department of General Dentistry of the Faculty of Advanced Dentistry of the Moscow State Medical University

T. D. Chirkova Ph.D., Associate Professor, Department of Faculty Therapeutic Dentistry, Moscow State Medical University

P. V. Kuprin Assistant, Department of General Dentistry, Department of General Practice Dentistry, FPDO MGMSU

Lack of adequate oral hygiene, combined with internal and external unfavorable factors, often leads to the development of inflammatory diseases of the periodontium (gingivitis, periodontitis) and the oral mucosa (stomatitis).

Pain in the gums, discomfort in the mouth, bad breath, bleeding gums both when brushing teeth and for no apparent reason are the main symptoms of an inflammatory process in the gums. Complex treatment indicated for this pathology includes many different components: professional oral hygiene, surgical methods, drug therapy, including various rinses that have antiseptic, antibacterial and anti-inflammatory effects. Essential oils and other components contained in medicinal plants that are part of the drug "Stomatofit® A" have antibacterial, antiseptic, and anti-inflammatory effects. They reduce inflammation of the oral mucosa and have a local anesthetic, softening and deodorizing effect. Benzocaine has a local anesthetic effect. Thickeners in the composition of “Stomatofit® A” help to retain the drug on the affected area, which ensures a longer effect.

CHAMOMILE FLOWERS (FLORES CHAMOMILLAE)

Contain compounds that have anti-inflammatory and antibacterial effects: essential oil containing bisabolol and bisabolol oxides, chamazulene, farnesene; flavonoids (apigenin, luteolin). Pharmacological and clinical studies have confirmed that chamomile extracts are growth inhibitors of Staphylococcus and Streptococcus strains and have a mycostatic effect.

OAK BARK (CORTEX QUERCUS)

The tannins in oak bark have a strong astringent effect. They form insoluble compounds with proteins, thereby protecting the surface of the oral mucosa and at the same time having a detrimental effect on microorganisms. Extracts from oak bark have an anti-inflammatory effect and reduce bleeding gums.

SAGE LEAVES (FOLIUM SALVIAE OFFICINALIS)

They contain essential oil with a strong antiseptic, bactericidal, mycostatic (mainly Candida albicans), antiviral effect, as well as a tannin with an astringent and anti-inflammatory effect. This composition makes sage leaves effective against inflammatory and infectious diseases of the oral mucosa.

ARNICA GRASS (HERBA ARNICAE)

It has an anti-edematous effect, promotes the growth of granulation tissue, and improves microcirculation processes. Essential oil and phenolcarboxylic acids determine the antiseptic and bactericidal effect.

Calamus rhizome (ACORUS CALAMIS L.)

Calamus extract is used externally for inflammation of the mouth and throat as a rinse and for some dermatoses as an antibacterial, antipruritic and anti-inflammatory bath agent (Oarowski, 1980).

PEPPERMINT (MENTHA PIPERITA L.)

According to the monographs of Commission E and ESCOP, peppermint leaf is a raw material that has an antispasmodic effect, enhances the secretion of digestive juices (including bile), and has antibacterial, analgesic and antiseptic effects.

Peppermint leaf is a typical oilseed raw material, essential oil is its main component. Contained in leaves in an amount of 0.5-4.0% (in some cultivated species up to 3.5%).

The main component of the oil is menthol (more than 50%). In addition, peppermint essential oil contains esters: acetate and valerian, menthone, phellandrene, pinene, cineol, mentofuran, piperitone, jasmon.

The components of peppermint leaf are also tannins 6-12%, flavonoids: luteolin, apigenin, diosmetin, bitterness, phenolic acids (Mills, Bone, 2000; Kohlmnzer, 2000). The component with the described activity is considered to be an essential oil that has an antiseptic effect, reduces sensitivity and at the same time stimulates nerve endings; tannins and flavonoids also participate in these therapeutic effects.

THYME HERB (THYMUS VULGARIS L.)

Thyme herb has a positive monograph of Commission E, ESCOP, monograph of the European Pharmacopoeia, DAB10, PF V. The scope of application, according to the monograph of Commission E, is symptoms of bronchial catarrh and whooping cough, catarrh of the upper respiratory tract (Komisja E., 1990). The ESCOP monograph expands the indications: inflammation of the oral cavity and bad breath (halithosis) (ESCOP, 1996).

Numerous pharmacological studies confirm the antispasmodic and expectorant, as well as antibacterial, antifungal and disinfectant effects of this raw material. Thyme oil has a strong antibacterial effect against both gram-negative and gram-positive strains. It also acts on fungi and yeasts, such as Candida albicans. This activity is due to the action of thymol and carvacrol.

The drug "Stomatofit® A" is a liquid extract from a mixture of medicinal plant materials (chamomile flowers, oak bark, sage leaves, arnica herb, calamus rhizomes, peppermint herb, common thyme herb) and anesthesin; has anti-inflammatory, astringent, antiseptic and local anesthetic effects. All of these components are well known: their pharmacological properties and clinical effectiveness have been proven by research by domestic and foreign scientists. The components of the drug are widely used in medicine, both independently and as part of various drugs.

25 g of the drug contains:

• Active components

Liquid extract from a mixture of raw materials (0.65:1.0) - 12,500 mg, containing: chamomile flowers (Matricaria chamomilla L) 1625 mg, oak bark (Quercus robur L) 1625 mg, sage leaves (Salvia officinalis L.) 1625 mg, arnica herb (Arnica Montana L.) 812 mg, calamus rhizomes (Acorus calamis L.) 812 mg, peppermint (Mentha piperita L) 812 mg, common thyme herb (Thymus vulgaris L.) 812 mg.

• Anestezin (benzocaine) 500 mg.

• Excipients

Sodium tetroborate, glycerin (glycerol), methylcellulose, ethanol 96%, purified water.

The drug is standardized for the content of essential oils (not less than 0.075%) and anesthesin (1.8-2.2%), as the main groups of compounds that determine therapeutic activity.

Essential oils and other components contained in these medicinal plants that are part of the drug "Stomatofit® A" have antibacterial, antiseptic, and anti-inflammatory effects. They reduce inflammation of the oral mucosa and have a local anesthetic, softening and deodorizing effect.

Benzocaine has a local anesthetic effect. Thickeners in the composition of “Stomatofit® A” help to retain the drug on the affected area, which ensures a longer effect.

PURPOSE OF THE STUDY

Evaluation of the effectiveness and safety of the use of the herbal preparation “Stomatofit® A” when used in the complex treatment of inflammatory diseases of the oral cavity.

MATERIALS AND METHODS OF RESEARCH

An open comparative, randomized study of the drug "Stomatofit® A" (manufacturer - joint stock company "Fitofarm Klenka", Poland) when used in the complex treatment of inflammatory diseases of the oral cavity in comparison with the effectiveness of the drug "Stomatofit®" in the complex treatment of inflammatory diseases of the oral cavity ( manufacturer - joint stock company "Fitofarm Klenka", Poland).

In accordance with the inclusion and exclusion criteria of the clinical trial protocol, the study included 120 patients who, according to the randomization plan set out in the protocol, were divided into the main (60 patients) and control groups (60 patients). The distribution of patients is presented in Table No. 1.

Table No. 1. Distribution of patients included in the study by gender and age

Under our supervision there were 120 patients diagnosed with: chronic catarrhal gingivitis in the acute stage (CHG) - 35 (main group); mild chronic generalized periodontitis in the acute stage (CHP LS) - 16 (main group); chronic generalized periodontitis of moderate severity (CGPS) - 9 (main group).

The control group included 36 patients with exacerbation of chronic catarrhal gingivitis, 16 patients with mild chronic generalized periodontitis and 8 patients with moderate chronic generalized periodontitis (CGPS), also in the acute stage (Fig. 1).

Rice. 1. Distribution of patients in the main and control groups by nosological forms

In accordance with the criteria for early termination of participation in the study and early termination of the study, approved in the clinical trial protocol, none of the patients in the main and control groups were prematurely excluded. Concomitant diseases of patients in the main and control groups are presented in Table No. 2.

Rice. 2. Final integration assessment of the effectiveness of the studied drugs

Pharmacotherapy for concomitant diseases of patients in the main and control groups did not change throughout the study and did not include drugs that affect the course of the clinical trial. The remaining patients of the main and control groups were practically healthy. After signing informed consent to participate in the study, patients of the main and control groups underwent a screening examination, which included:

• assessment of compliance with inclusion/exclusion criteria;
• registration of demographic data (date of birth, gender);
• collecting a medical history, including past illnesses and surgeries;
• objective examination;
• questioning;
• registration of medication prescriptions in the three-month period preceding the study;

Physical examination:

• according to indications;
• X-ray methods;
• ECG, blood pressure, pulse;
• clinical and biochemical blood test (total protein, ALT, AST, glucose, urea, creatinine).

After the examination, patients received medications and began taking them.

Table No. 2. Concomitant diseases of patients of the main and control groups

PRESCRIPTION SCHEME OF STUDY DRUGS

Patients of both groups with chronic catarrhal gingivitis in the acute stage and periodontitis of mild and moderate severity in the acute stage received adequate treatment (removal of supra- and subgingival deposits, professional oral hygiene, curettage), corresponding to the initial stage of treatment of inflammatory periodontal diseases.

Patients in the main group were prescribed the drug "Stomatofit® A". The affected areas were smeared with the drug, previously applied to a cotton swab, four times a day. Immediately after using the drug, patients refrained from eating and rinsing the mouth. The duration of the course is 7 days.

Patients in the control group were prescribed the drug "Stomatofit®" in the form of mouth rinses with a 15% aqueous solution of the drug four times a day (7.5 ml of the drug dissolved in 1/4 cup of boiled water). The duration of the course is 7 days. Control medical examinations were carried out on the third, fifth and seventh days of the study.

During the study, patients were prohibited from using medications that could affect the study results:

• use of non-steroidal anti-inflammatory drugs;
• use of GCS for systemic therapy;
• use of antibacterial agents;
• rinsing the mouth with chlorhexidine;
• rinsing the mouth with antiseptic and/or astringent solutions.

The effectiveness of therapy was assessed using the following parameters:

1. Assessment of the level of oral hygiene based on the dynamics of the OHI-S oral hygiene index.
2. Assessment of the dynamics of the inflammatory process in the gums using the PMA index.
3. Assessment of gum bleeding using the PBI (papilla bleeding index): Muehlemann, Son (1971).
4. Assessment of the severity of pain using VAS (visual analogue scale) on a ten-point system.
5. Integral efficiency assessment.

The subjective assessment of the results of treatment by the patient and the assessment of the results of treatment by the doctor and compliance were taken into account.

Data from medical examinations and laboratory test results were entered into individual patient records and subjected to statistical processing.

Assessment of tolerability and safety of study drugs

Tolerability and safety assessments were based on subjective complaints and objective data obtained during the study. The dynamics of clinical and biochemical blood test parameters (total protein, ALT, AST, glucose, urea, creatinine), frequency of occurrence and nature of side effects were taken into account.

Tolerability of the drug was assessed using objective and subjective data (Table No. 3) and in points.

Table No. 3. Tolerability of the drug

RESEARCH RESULTS AND DISCUSSION

The use of the drug "Stomatofit® A" in the complex treatment of inflammatory periodontal diseases did not reveal any adverse reactions that had a significant negative impact on the patient's condition, requiring discontinuation of the drug and additional medical measures. The safety of “Stomatofit® A” is confirmed by laboratory data (Table No. and the positive dynamics of clinical symptoms.

The effectiveness of the drug "Stomatofit® A" is confirmed by analyzing the dynamics of the main clinical symptoms in patients of the main group. Prescribing "Stomatofit® A" to patients in combination with professional hygiene significantly increased the level of oral hygiene (Table No. 4). Thus, the UIG from 2.76 ± 0.18 at the first visit decreased significantly by the second visit to 0.29 ± 0.05; by the end of treatment in patients of the main group, the level of oral hygiene became satisfactory (UIG - 0). In the control group, in which patients used rinsing with Stomatofit®, a significant increase in the level of oral hygiene was also observed: IIG decreased from 2.42 ± 0.18 to 0.075 ± 0.03 at the end of the treatment course.

Table No. 4. Dynamics of the oral hygiene indicator in patients of the main and control groups during therapy (OHI-S oral hygiene index)

* p < 0.05 - the probability of differences is indicated in comparison with the beginning of the study

It should be noted that no significant difference in the results of the influence of the use of “Stomatofit® A” and “Stomatofit®” was identified. The dynamics of the results are similar (p > 0.05).

The use of "Stomatofit® A" in combination with professional oral hygiene showed a decrease in gum bleeding from 3.1 ± 0.09 to 2.2 ± 0.09 by the second visit (Table No. 5), by the third - to 1.33 ± 0.09, by the fourth visit, gum bleeding was practically absent in 76% (23 patients). In the control group, the use of the comparison drug also revealed a positive trend in reducing bleeding. By the end of treatment, bleeding persisted in the form of single pinpoint bleeding. A steady decrease in signs of inflammation was confirmed by the positive dynamics of the PMA index in both groups; a more intense anti-inflammatory reaction was observed in the main group (Table No. 6).

Table No. 5. Assessment of bleeding gums using the PBI bleeding index (papilla bleeding index), Muleman, Son (1971)

* p < 0.05 - the probability of differences is indicated in comparison with the beginning of the study

Table No. 6. Inflammation assessment using the PMA index

* p < 0.05 - the probability of differences is indicated in comparison with the beginning of the study

By the end of the course of treatment, inflammation of the interdental papillae remained in 13% (4 patients) in the main group and in 16% (5 patients) in the control group, respectively, RMA decreased from 55.3 ± 2.7 to 2.9 ± 1.36 in the main group, in the control group - from 43.25 ± 1.8 to 8.9 ± 1.36.

Since exacerbation of inflammatory periodontal diseases is accompanied by pain of varying severity, great importance was attached to the analysis of the analgesic effect of “Stomatofit® A” (Table No. 7).

Table No. 7. Assessment of the severity of pain using VAS (visual analogue scale) on a ten-point system

* p < 0.05 - the probability of differences is indicated in comparison with the beginning of the study

Comparison of changes in the severity of pain according to VAS in the main and control groups revealed significant differences in the analgesic effect of the drug “Stomatofit® A”, this is especially noticeable at the end of treatment (visits 3 and 4). Thus, in patients of the main group, by the third visit, pain decreased from 7.1 ± 0.22 to 2.9 ± 0.18 points and decreased significantly by the end of the course of treatment (1.86 ± 0.13) (Table No. 7) .

The use of the comparison drug "Stomatofit®" showed a moderate analgesic effect, the pain syndrome decreased from 5.87 ± 0.27 to 4.5 ± 0.22 by the second visit, to 3.3 ± 0.27 by the third and practically remained the same the same level by the fourth visit - 3.1 ± 0.18.

The inclusion of the anesthetic component anesthesin in the composition of the drug significantly increased the analgesic effect of the drug compared to Stomatofit®, as can be seen from the data in Table No. 7.

Analysis of the dynamics of biochemical and clinical blood tests did not reveal any significant changes. There were no significant deviations from the norm in the blood (Table No. 8).

Table No. 8. Data from laboratory tests in patients of the main and control groups

During observation of the patients of the main group, not a single adverse event was registered, which, along with the absence of negative dynamics in laboratory and clinical studies, allows us to recognize the tolerability of “Stomatofit® A” as good. The absence of side effects of Stomatofit® A is confirmed by the assessment of the tolerability of the studied drugs by the doctor and patients (Fig. 2). The drug "Stomatofit® A" demonstrated high anti-inflammatory activity and a pronounced analgesic effect, which was determined by the content of anesthesin in the composition. "Stomatofit® A" is easy to use, the patient can use it independently in accordance with the recommendations of the attending physician.

CONCLUSIONS

The use of the drug “Stomatofit® A”, which has antibacterial activity, in the complex treatment of inflammatory periodontal diseases contributes to the complete normalization of the hygienic state of the oral cavity (UIG, visit 1 - 2.76 ± 0.18, GI at the end of treatment - 0).

The use of "Stomatofit® A" leads to a significant decrease in the PMA index (from 55.3 ± 2.7% to 2.9 ± 1.36%), which is due to the anti-inflammatory effect of the drug.

Therapy with “Stomatofit® A” in combination with oral hygiene helps to significantly reduce bleeding gums, reducing the bleeding index from 3.1 ± 0.09 to 0.83 ± 0.04.

“Stomatofit® A” has a pronounced analgesic effect and helps reduce the severity of pain (from 7.1 ± 0.22 to 1.86 ± 0.13 according to VAS).

An analysis of the dynamics of the main clinical symptoms of inflammatory periodontal diseases showed that the therapeutic effectiveness of Stomatofit® A is comparable to the effectiveness of the reference drug Stomatofit®. At the same time, the analgesic effect of “Stomatofit® A” significantly (p < 0.05) exceeds the effect of the comparison drug.

The absence of undesirable side effects has proven the safety of using “Stomatofit® A”, taking into account the individual tolerability of the drug components. The positive dynamics of clinical symptoms, confirmed by the results of the index assessment, proved the high effectiveness of the drug.

CONCLUSION

Based on the results of the studies, it should be concluded that the drug “Stomatofit® A” has a pronounced therapeutic effect when used in the complex treatment and prevention of inflammatory periodontal diseases (Fig. 2). An excellent effect of using “Stomatofit® A” was noted by 53% (32 patients), a good effect by 47% (28 patients). 47% (28 patients) noted the treatment of inflammatory periodontal diseases with “Stomatofit®” as excellent, a good effect was observed in 43% (26 patients), a satisfactory effect was noted by 10% (6 patients) (Fig. 2).

“Stomatofit® A” is easy to use, easily applied to the gums and is well appreciated by patients, has a pleasant herbaceous taste, and no adverse reactions have been observed in any case.

The drug "Stomatofit®" can be recommended for use in the dosage recommended by the manufacturer in the complex therapy of inflammatory periodontal diseases.